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Diethylstilbestrol is generally well tolerated in female dogs. A mild side effect of diethylstilbestrol may include some blood spotting from the vagina in unspayed female dogs. Serious side effects are generally associated with。

Other side effects include signs of being in heat, including vaginal discharge or spotting, infection of the uterus in intact female dogs (pyometra), cystic endometrial hyperplasia and other abnormalities of the reproductive system, diarrhea, vomiting, lack of energy,。

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